Biguanides. A review of history, pharmacodynamics and therapy.
G Schäfer - Diabete & metabolisme, 1983 - europepmc.org
G Schäfer
Diabete & metabolisme, 1983•europepmc.orgThis review on biguanides gives a general survey of biguanide actions on many metabolic
models in vivo and in vitro. It focuses especially on the comparison of the 3 antidiabetic
biguanides, of which metformin is discussed as the only oral antidiabetic biguanide useful in
treatment of type-II diabetes with a minimum risk of side effects when applied in a well
controlled regime. Pharmacokinetics, pharmacodynamics, hypotheses on the molecular
mode of action, and implications for therapy are discussed.
models in vivo and in vitro. It focuses especially on the comparison of the 3 antidiabetic
biguanides, of which metformin is discussed as the only oral antidiabetic biguanide useful in
treatment of type-II diabetes with a minimum risk of side effects when applied in a well
controlled regime. Pharmacokinetics, pharmacodynamics, hypotheses on the molecular
mode of action, and implications for therapy are discussed.
This review on biguanides gives a general survey of biguanide actions on many metabolic models in vivo and in vitro. It focuses especially on the comparison of the 3 antidiabetic biguanides, of which metformin is discussed as the only oral antidiabetic biguanide useful in treatment of type-II diabetes with a minimum risk of side effects when applied in a well controlled regime. Pharmacokinetics, pharmacodynamics, hypotheses on the molecular mode of action, and implications for therapy are discussed.
europepmc.org