[HTML][HTML] Polyunsaturated fatty acids suppress hepatic sterol regulatory element-binding protein-1 expression by accelerating transcript decay
J Xu, M Teran-Garcia, JHY Park, MT Nakamura… - Journal of Biological …, 2001 - ASBMB
The reduction in hepatic abundance ofsterol regulatory element binding protein-1 (SREBP-
1) mRNA and protein associated with the ingestion of polyunsaturated fatty acids (PUFA)
appears to be largely responsible for the PUFA-dependent inhibition of lipogenic gene
transcription. Our initial studies indicated that the induction ofSREBP-1 expression by insulin
and glucose was blocked by PUFA. Nuclear run-on assays suggested PUFA reduced
SREBP-1mRNA by post-transcriptional mechanisms. In this report we demonstrate that …
1) mRNA and protein associated with the ingestion of polyunsaturated fatty acids (PUFA)
appears to be largely responsible for the PUFA-dependent inhibition of lipogenic gene
transcription. Our initial studies indicated that the induction ofSREBP-1 expression by insulin
and glucose was blocked by PUFA. Nuclear run-on assays suggested PUFA reduced
SREBP-1mRNA by post-transcriptional mechanisms. In this report we demonstrate that …