[HTML][HTML] Pivotal role of ABCA1 in reverse cholesterol transport influencing HDL levels and susceptibility to atherosclerosis
The identification of mutations in ABCA1 in patients with Tangier disease and familial HDL
deficiency demonstrated that inadequate transport of phospholipid and cholesterol to the
extracellular space results in the hypercatabolism of lipid-poor nascent HDL particles.
However, the relationship between changes in ABCA1 activity and HDL levels is not clear.
To address this question directly in vivo, we have used bacterial artificial chromosome
transgenic approaches, which allow for appropriate developmental and cellular localization …
deficiency demonstrated that inadequate transport of phospholipid and cholesterol to the
extracellular space results in the hypercatabolism of lipid-poor nascent HDL particles.
However, the relationship between changes in ABCA1 activity and HDL levels is not clear.
To address this question directly in vivo, we have used bacterial artificial chromosome
transgenic approaches, which allow for appropriate developmental and cellular localization …
