Molecular imaging and targeted drug delivery with a novel, ligand-directed paramagnetic nanoparticle technology
GM Lanza, DR Abendschein, X Yu… - Academic …, 2002 - academicradiology.org
Rationale and Objectives Ligand-based targeting is a versatile method that allows high
capacity pharmaceutical carriers such as polymers, microparticles, cell ghosts, and
liposomes to be directed to pathological tissues in vivo. Targeted drug delivery systems offer
the potential safety and efficacy benefits of high local drug tissue levels while maintaining
low overall systemic concentrations. Unfortunately, traditional blood level monitoring of
ligand-based therapy systems does not provide inference to accumulated drug …
capacity pharmaceutical carriers such as polymers, microparticles, cell ghosts, and
liposomes to be directed to pathological tissues in vivo. Targeted drug delivery systems offer
the potential safety and efficacy benefits of high local drug tissue levels while maintaining
low overall systemic concentrations. Unfortunately, traditional blood level monitoring of
ligand-based therapy systems does not provide inference to accumulated drug …
