[HTML][HTML] Oligomerization of wild type and nonfunctional mutant angiotensin II type I receptors inhibits Gαq protein signaling but not ERK activation
JL Hansen, J Theilade, S Haunsø, SP Sheikh - Journal of Biological …, 2004 - ASBMB
The 7-transmembrane or G protein-coupled receptors relay signals from hormones and
sensory stimuli to multiple signaling systems at the intracellular face of the plasma
membrane including heterotrimeric G proteins, ERK1/2, and arrestins. It is an emerging
concept that 7-transmembrane receptors form oligomers; however, it is not well understood
which roles oligomerization plays in receptor activation of different signaling systems. To
begin to address this question, we used the angiotensin II type 1 (AT 1) receptor, a key …
sensory stimuli to multiple signaling systems at the intracellular face of the plasma
membrane including heterotrimeric G proteins, ERK1/2, and arrestins. It is an emerging
concept that 7-transmembrane receptors form oligomers; however, it is not well understood
which roles oligomerization plays in receptor activation of different signaling systems. To
begin to address this question, we used the angiotensin II type 1 (AT 1) receptor, a key …
