[HTML][HTML] Translational regulation of human neuronal nitric-oxide synthase by an alternatively spliced 5′-untranslated region leader exon
Expression of the neuronal nitric-oxide synthase (nNOS) mRNA is subject to complex cell-
specific transcriptional regulation, which is mediated by alternative promoters.
Unexpectedly, we identified a 89-nucleotide alternatively spliced exon located in the 5′-
untranslated region between exon 1 variants and a common exon 2 that contains the
translational initiation codon. Alternative splicing events that do not affect the open reading
frame are distinctly uncommon in mammals; therefore, we assessed its functional relevance …
specific transcriptional regulation, which is mediated by alternative promoters.
Unexpectedly, we identified a 89-nucleotide alternatively spliced exon located in the 5′-
untranslated region between exon 1 variants and a common exon 2 that contains the
translational initiation codon. Alternative splicing events that do not affect the open reading
frame are distinctly uncommon in mammals; therefore, we assessed its functional relevance …
