Novel role of cold/menthol-sensitive transient receptor potential melastatine family member 8 (TRPM8) in the activation of store-operated channels in LNCaP human …
Recent cloning of a cold/menthol-sensitive TRPM8 channel (transient receptor potential
melastatine family member 8) from rodent sensory neurons has provided the molecular
basis for the cold sensation. Surprisingly, the human orthologue of rodent TRPM8 also
appears to be strongly expressed in the prostate and in the prostate cancer-derived
epithelial cell line, LNCaP. In this study, we show that despite such expression, LNCaP cells
respond to cold/menthol stimulus by membrane current (I cold/menthol) that shows inward …
melastatine family member 8) from rodent sensory neurons has provided the molecular
basis for the cold sensation. Surprisingly, the human orthologue of rodent TRPM8 also
appears to be strongly expressed in the prostate and in the prostate cancer-derived
epithelial cell line, LNCaP. In this study, we show that despite such expression, LNCaP cells
respond to cold/menthol stimulus by membrane current (I cold/menthol) that shows inward …
