Ca2+ pools and cell growth: Evidence for sarcoendoplasmic Ca2+-ATPases 2B involvement in human prostate cancer cell growth control
G Legrand, S Humez, C Slomianny, E Dewailly… - Journal of Biological …, 2001 - ASBMB
The present study demonstrates for the first time that intracellular calcium-ATPases and
calcium pool content are closely associated with prostate cancer LNCaP cell growth. Cell
growth was modulated by changing the amount of epidermal growth factor, serum, and
androgene in culture media. Using the microspectrofluorimetric method with Fura-2 and Mag
Fura-2 as probes, we show that in these cells, the growth rate is correlated with intracellular
calcium pool content. Indeed, an increased growth rate is correlated with an increase in the …
calcium pool content are closely associated with prostate cancer LNCaP cell growth. Cell
growth was modulated by changing the amount of epidermal growth factor, serum, and
androgene in culture media. Using the microspectrofluorimetric method with Fura-2 and Mag
Fura-2 as probes, we show that in these cells, the growth rate is correlated with intracellular
calcium pool content. Indeed, an increased growth rate is correlated with an increase in the …
