[HTML][HTML] Autophosphorylation-dependent targeting of calcium/calmodulin-dependent protein kinase II by the NR2B subunit of theN-methyl-D-aspartate receptor
S Strack, RJ Colbran - Journal of Biological Chemistry, 1998 - ASBMB
Activation and Thr 286 autophosphorylation of calcium/calmodulindependent kinase II
(CaMKII) following Ca 2+ influx viaN-methyl-d-aspartate (NMDA)-type glutamate receptors is
essential for hippocampal long term potentiation (LTP), a widely investigated cellular model
of learning and memory. Here, we show that NR2B, but not NR2A or NR1, subunits of NMDA
receptors are responsible for autophosphorylation-dependent targeting of CaMKII. CaMKII
and NMDA receptors colocalize in neuronal dendritic spines, and a CaMKII· NMDA receptor …
(CaMKII) following Ca 2+ influx viaN-methyl-d-aspartate (NMDA)-type glutamate receptors is
essential for hippocampal long term potentiation (LTP), a widely investigated cellular model
of learning and memory. Here, we show that NR2B, but not NR2A or NR1, subunits of NMDA
receptors are responsible for autophosphorylation-dependent targeting of CaMKII. CaMKII
and NMDA receptors colocalize in neuronal dendritic spines, and a CaMKII· NMDA receptor …
