A clinicopathologic study of 100 cases of Parkinson's disease
AJ Hughes, SE Daniel, S Blankson… - Archives of …, 1993 - jamanetwork.com
• The clinical details of 100 cases of histologically confirmed Parkinson's disease were
examined and correlated with pathologic findings. Age at disease onset (mean, 62.4 years),
disease duration (mean, 13.1 years), and age at death (mean, 75.5 years) were similar to
those in previous smaller series. Asymmetric, tremulous onset was most common, although
23% of patients had no rest tremor. Motor fluctuations and dyskinesias occurred in 60% of
levodopa-treated patients. All patients had clinical parkinsonism; however, 12 had atypical …
examined and correlated with pathologic findings. Age at disease onset (mean, 62.4 years),
disease duration (mean, 13.1 years), and age at death (mean, 75.5 years) were similar to
those in previous smaller series. Asymmetric, tremulous onset was most common, although
23% of patients had no rest tremor. Motor fluctuations and dyskinesias occurred in 60% of
levodopa-treated patients. All patients had clinical parkinsonism; however, 12 had atypical …
