CCR11 is a functional receptor for the monocyte chemoattractant protein family of chemokines
VL Schweickart, A Epp, CJ Raport, PW Gray - Journal of Biological …, 2000 - ASBMB
Chemokines mediate their diverse activities through G protein-coupled receptors. The
human homolog of the bovine orphan receptor PPR1 shares significant similarity to
chemokine receptors. Transfection of this receptor into murine L1. 2 cells resulted in
responsiveness to monocyte chemoattractant protein (MCP)-4, MCP-2, and MCP-1 in
chemotaxis assays. Binding studies with radiolabeled MCP-4 demonstrated a single high
affinity binding site with an IC 50 of 0.14 nm. As shown by competition binding, other …
human homolog of the bovine orphan receptor PPR1 shares significant similarity to
chemokine receptors. Transfection of this receptor into murine L1. 2 cells resulted in
responsiveness to monocyte chemoattractant protein (MCP)-4, MCP-2, and MCP-1 in
chemotaxis assays. Binding studies with radiolabeled MCP-4 demonstrated a single high
affinity binding site with an IC 50 of 0.14 nm. As shown by competition binding, other …
