[HTML][HTML] SREBP-1 interacts with hepatocyte nuclear factor-4α and interferes with PGC-1 recruitment to suppress hepatic gluconeogenic genes
T Yamamoto, H Shimano, Y Nakagawa, T Ide… - Journal of Biological …, 2004 - ASBMB
The hepatocyte nuclear factor-4α (HNF-4α)/PGC-1 pathway plays a crucial role in the
transcriptional regulation of hepatic gluconeogenic enzymes such as phosphoenolpyruvate
carboxykinase (PEPCK) and Glc-6-Pase, genes that are activated at fasting and suppressed
in a fed state. SREBP-1c dominates the nutritional regulation of lipogenic genes inverse to
gluconeogenesis. Here we show the mechanism by which SREBP-1 suppresses expression
of gluconeogenic genes. A series of luciferase reporter assays demonstrated that SREBP-1a …
transcriptional regulation of hepatic gluconeogenic enzymes such as phosphoenolpyruvate
carboxykinase (PEPCK) and Glc-6-Pase, genes that are activated at fasting and suppressed
in a fed state. SREBP-1c dominates the nutritional regulation of lipogenic genes inverse to
gluconeogenesis. Here we show the mechanism by which SREBP-1 suppresses expression
of gluconeogenic genes. A series of luciferase reporter assays demonstrated that SREBP-1a …
