Ductus arteriosus responses to prostaglandin E1 at high and low oxygen concentrations
RI Clyman, MA Heymann, AM Rudolph - Prostaglandins, 1977 - Elsevier
It previously has been suggested that prostaglandin E 1 (PGE 1) relaxes the ductus
arteriosus in a low but not in an elevated oxygen environment. However, in the experiments
reported here PGE 1 relaxed rings on fetal lamb ductus arteriosus in vitro at both low (14 to
20 torr) and high (680 to 720 torr) oxygen tensions. The threshold concentration for PGE 1
was 10− 10 M in either PO 2 and the ED50's of PGE 1 relaxation in high and low oxygen
were 8.5±3.4× 10− 10 M and 5.5±0.7× 10− 10 M respectively. The magnitude of the …
arteriosus in a low but not in an elevated oxygen environment. However, in the experiments
reported here PGE 1 relaxed rings on fetal lamb ductus arteriosus in vitro at both low (14 to
20 torr) and high (680 to 720 torr) oxygen tensions. The threshold concentration for PGE 1
was 10− 10 M in either PO 2 and the ED50's of PGE 1 relaxation in high and low oxygen
were 8.5±3.4× 10− 10 M and 5.5±0.7× 10− 10 M respectively. The magnitude of the …