Matrix metalloproteinases are differentially expressed in adipose tissue during obesity and modulate adipocyte differentiation
C Chavey, B Mari, MN Monthouel, S Bonnafous… - Journal of Biological …, 2003 - ASBMB
Matrix metalloproteinases (MMPs) are essential for proper extracellular matrix remodeling, a
process that takes place during obesity-mediated adipose tissue formation. Here, we
examine expression profiles and the potential role of MMPs and their tissue inhibitors
(TIMPs) in adipose tissue remodeling during obesity. Expression patterns are studied by
Northern blot and real-time PCR in two genetic models of obesity (ob/ob and db/db mice)
and in a diet-induced model of obesity (AKR mice). Of the MMPs and TIMPs studied, mRNA …
process that takes place during obesity-mediated adipose tissue formation. Here, we
examine expression profiles and the potential role of MMPs and their tissue inhibitors
(TIMPs) in adipose tissue remodeling during obesity. Expression patterns are studied by
Northern blot and real-time PCR in two genetic models of obesity (ob/ob and db/db mice)
and in a diet-induced model of obesity (AKR mice). Of the MMPs and TIMPs studied, mRNA …
