Analysis of pfmdr1 and drug susceptibility in fresh isolates of Plasmodium falciparum from subsaharan Africa
LK Basco, J Le Bras, Z Rhoades, CM Wilson - Molecular and biochemical …, 1995 - Elsevier
Resistance of Plasmodium falciparum to many therapeutic agents is an increasing problem
in most endemic areas. The role of the mdr-like gene products of P. falciparum in resistance
to quinoline-containing compounds is not clear. The purpose of this study was to further
examine the role of pfmdr1 in drug resistance in fresh clinical isolates originating from Africa.
Drug susceptibility testing (chloroquine, mefloquine, halofantrine and quinine) and a
molecular analysis of pfmdr1 was completed for 51 fresh clinical isolates. A statistical …
in most endemic areas. The role of the mdr-like gene products of P. falciparum in resistance
to quinoline-containing compounds is not clear. The purpose of this study was to further
examine the role of pfmdr1 in drug resistance in fresh clinical isolates originating from Africa.
Drug susceptibility testing (chloroquine, mefloquine, halofantrine and quinine) and a
molecular analysis of pfmdr1 was completed for 51 fresh clinical isolates. A statistical …
