[HTML][HTML] Generation of soluble leptin receptor by ectodomain shedding of membrane-spanning receptors in vitro and in vivo
H Ge, L Huang, T Pourbahrami, C Li - Journal of Biological Chemistry, 2002 - ASBMB
Leptin is an adipocyte-derived hormone with potent effects on food intake and body weight.
Genetically obese rodents with mutations of leptin or leptin receptor develop morbid obesity
and diabetes. The receptor for leptin, OB-R, is alternatively spliced to at least five transcripts,
encoding receptors designated OB-Ra,-b,-c,-d, and-e. OB-Re does not encode a
transmembrane domain and is secreted. In humans, transcripts corresponding to OB-Re
have not been discovered. However, soluble leptin receptor does circulate in human plasma …
Genetically obese rodents with mutations of leptin or leptin receptor develop morbid obesity
and diabetes. The receptor for leptin, OB-R, is alternatively spliced to at least five transcripts,
encoding receptors designated OB-Ra,-b,-c,-d, and-e. OB-Re does not encode a
transmembrane domain and is secreted. In humans, transcripts corresponding to OB-Re
have not been discovered. However, soluble leptin receptor does circulate in human plasma …
