[HTML][HTML] Increased β-oxidation in muscle cells enhances insulin-stimulated glucose metabolism and protects against fatty acid-induced insulin resistance despite …
G Perdomo, SR Commerford, AMT Richard… - Journal of Biological …, 2004 - ASBMB
Skeletal muscle insulin resistance may be aggravated by intramyocellular accumulation of
fatty acid-derived metabolites that inhibit insulin signaling. We tested the hypothesis that
enhanced fatty acid oxidation in myocytes should protect against fatty acid-induced insulin
resistance by limiting lipid accumulation. L6 myotubes were transduced with adenoviruses
encoding carnitine palmitoyltransferase I (CPT I) isoforms or β-galactosidase (control). Two
to 3-fold overexpression of L-CPT I, the endogenous isoform in L6 cells, proportionally …
fatty acid-derived metabolites that inhibit insulin signaling. We tested the hypothesis that
enhanced fatty acid oxidation in myocytes should protect against fatty acid-induced insulin
resistance by limiting lipid accumulation. L6 myotubes were transduced with adenoviruses
encoding carnitine palmitoyltransferase I (CPT I) isoforms or β-galactosidase (control). Two
to 3-fold overexpression of L-CPT I, the endogenous isoform in L6 cells, proportionally …
