The Transcription Factor Spi-1/PU. 1 Binds RNA and Interferes with the RNA-binding Protein p54nrb (∗)
M Hallier, A Tavitian, F Moreau-Gachelin - Journal of Biological Chemistry, 1996 - ASBMB
The protooncogene for Spi-1/PU. 1 is an Ets-related transcription factor overexpressed
during Friend erythroleukemia. The molecular basis by which Spi-1/PU. 1 is involved in the
erythroleukemic process remains to be elucidated. By using an immobilized protein binding
assay, we have identified a 55-kDa protein as a putative partner of Spi-1/PU. 1 protein.
Microsequence analysis revealed that this 55-kDa protein was p54 nrb (nuclear RNA-
binding protein, 54 kDa) a RNA-binding protein highly similar to the splicing factor PSF …
during Friend erythroleukemia. The molecular basis by which Spi-1/PU. 1 is involved in the
erythroleukemic process remains to be elucidated. By using an immobilized protein binding
assay, we have identified a 55-kDa protein as a putative partner of Spi-1/PU. 1 protein.
Microsequence analysis revealed that this 55-kDa protein was p54 nrb (nuclear RNA-
binding protein, 54 kDa) a RNA-binding protein highly similar to the splicing factor PSF …
