Species-and tissue-dependent effects of NO and cyclic GMP on cardiac ion channels
R Fischmeister, L Castro, A Abi-Gerges… - … and Physiology Part A …, 2005 - Elsevier
Biochemical studies have established the presence of a NO pathway in the heart, including
sources of NO and various effectors. Several cardiac ion channels have been shown to be
modified by NO, such as L-type Ca2+, ATP-sensitive K+, and pacemaker f-channels. Some
of these effects are mediated by cGMP, through the activity of three main proteins: the cGMP-
dependent protein kinase (PKG), the cGMP-stimulated phosphodiesterase (PDE2) and the
cGMP-inhibited PDE (PDE3). Other effects appear independent of cGMP, as for instance the …
sources of NO and various effectors. Several cardiac ion channels have been shown to be
modified by NO, such as L-type Ca2+, ATP-sensitive K+, and pacemaker f-channels. Some
of these effects are mediated by cGMP, through the activity of three main proteins: the cGMP-
dependent protein kinase (PKG), the cGMP-stimulated phosphodiesterase (PDE2) and the
cGMP-inhibited PDE (PDE3). Other effects appear independent of cGMP, as for instance the …
