The inflammatory response to implanted biomaterials severely limits their deployment in
patients. Plasminogen has been shown to play a central role in cell migration, and therefore
could regulate this inflammatory response. We sought to determine if plasminogen
influences recruitment of inflammatory cells to a biomaterial implanted into plasminogen‐
deficient (Plg–/–) mice. Small disks of polyethylene terephthalate, a material used in
vascular grafts, were surgically implanted into the peritoneum of wild‐type and Plg–/–mice …