Protein palmitoylation plays a critical role in sorting and targeting of several proteins to pre-
and postsynaptic sites. In this study, we have analyzed the role of palmitoylation in trafficking
of synaptotagmin I and its modulation by synaptic activity. We found that palmitoylation of N-
terminal cysteines contributed to sorting of synaptotagmin I to an intracellular vesicular
compartment at the presynaptic terminal. Presynaptic targeting is a unique feature of N-
terminal sequences of synaptotagmin I because the palmitoylated N terminus of …