Purification and use of recombinant inhibitor of apoptosis proteins as caspase inhibitors
QL Deveraux, K Welsh, JC Reed - Methods in Enzymology, 2000 - Elsevier
Cell death proteases, known as “caspases,” are highly conserved and integral components
of both initiation and execution of apoptotic programs in diverse species. 1, 2, 3, 4, 5
Caspase inhibitors, including (1) the aldehyde and fluoro-or chloromethyl ketone versions of
synthetic peptide substrates and (2) the viral caspase inhibitors CrmA and p35, have been
powerful tools for the investigation of cell death programs. 6, 7, 8, 9, 10, 11, 12, 13, 14, 15,
16, 17 Several human proteins from the inhibitor of apoptosis family (IAPs) were shown to …
of both initiation and execution of apoptotic programs in diverse species. 1, 2, 3, 4, 5
Caspase inhibitors, including (1) the aldehyde and fluoro-or chloromethyl ketone versions of
synthetic peptide substrates and (2) the viral caspase inhibitors CrmA and p35, have been
powerful tools for the investigation of cell death programs. 6, 7, 8, 9, 10, 11, 12, 13, 14, 15,
16, 17 Several human proteins from the inhibitor of apoptosis family (IAPs) were shown to …
