[PDF][PDF] Signal strength dictates PI3K contribution to Ras/ERK1-2 activation via differential Gab1/Shp2 recruitment: consequences for resistance to EGFR inhibition
C Sampaio, M Dance, A Montagner, T Edouard… - Mol. Cell. Biol, 2008 - Citeseer
Mol. Cell. Biol, 2008•Citeseer
Signal Strength Dictates PI3K Contribution to Ras/ERK1-2 Activation via Differential Gab1/Shp2
Recruitment: Consequences for Res Page 1 Signal Strength Dictates PI3K Contribution to
Ras/ERK1-2 Activation via Differential Gab1/Shp2 Recruitment: Consequences for Resistance
to EGFR Inhibition Carla Sampaio 1,2 , Marie Dance 1,2 , Alexandra Montagner 2 , Thomas
Edouard 2 , Nicole Malet 2 , Bertrand Perret 2,3 , Armelle Yart 2 , Jean-Pierre Salles 2,3 , and
Patrick Raynal 2,3* 5 1 These authors contributed equally to the work INSERM U563 …
Recruitment: Consequences for Res Page 1 Signal Strength Dictates PI3K Contribution to
Ras/ERK1-2 Activation via Differential Gab1/Shp2 Recruitment: Consequences for Resistance
to EGFR Inhibition Carla Sampaio 1,2 , Marie Dance 1,2 , Alexandra Montagner 2 , Thomas
Edouard 2 , Nicole Malet 2 , Bertrand Perret 2,3 , Armelle Yart 2 , Jean-Pierre Salles 2,3 , and
Patrick Raynal 2,3* 5 1 These authors contributed equally to the work INSERM U563 …
Abstract
PI3K participates in ERK1-2 activation according to signal strength, through unknown mechanisms. We report herein that Gab1/Shp2 constitutes a PI3K-dependent checkpoint of
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