The αβ versus γδ T-cell lineage choice
E Robey, BJ Fowlkes - Current opinion in immunology, 1998 - Elsevier
E Robey, BJ Fowlkes
Current opinion in immunology, 1998•ElsevierDuring thymic development, immature T cells rearrange and express the genes encoding
the T-cell antigen receptor and mature as either αβ or γδ lineage T cells. In the past year,
advances have been made in understanding the role of individual components of the T-cell
antigen receptor complex in the development of αβ and γδ lineage T cells. In addition, the
transmembrane receptor Notch has recently been implicated as a new player in αβ versus
γδ lineage determination.
the T-cell antigen receptor and mature as either αβ or γδ lineage T cells. In the past year,
advances have been made in understanding the role of individual components of the T-cell
antigen receptor complex in the development of αβ and γδ lineage T cells. In addition, the
transmembrane receptor Notch has recently been implicated as a new player in αβ versus
γδ lineage determination.
During thymic development, immature T cells rearrange and express the genes encoding the T-cell antigen receptor and mature as either αβ or γδ lineage T cells. In the past year, advances have been made in understanding the role of individual components of the T-cell antigen receptor complex in the development of αβ and γδ lineage T cells. In addition, the transmembrane receptor Notch has recently been implicated as a new player in αβ versus γδ lineage determination.
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