For largely unknown reasons, biopharmaceuticals evoke potentially harmful antibody
formation. Such antibodies can inhibit drug efficacy and, when directed against endogenous
proteins, cause life-threatening complications. Insight into the mechanisms by which
biopharmaceuticals break tolerance and induce an immune response will contribute to
finding solutions to prevent this adverse effect. Using a transgenic mouse model, we here
demonstrate that protein misfolding, detected with the use of tissue-type plasminogen …