The intrinsic pathway of coagulation is essential for thrombus stability in mice
T Renné, B Nieswandt, D Gailani - Blood Cells, Molecules, and Diseases, 2006 - Elsevier
Blood coagulation is a highly regulated process involving interactions between platelets,
plasma coagulation factors, and the vessel wall. During coagulation in vivo, fibrin formation
is thought to be initiated when plasma factor VIIa forms a complex with the membrane
protein tissue factor. Coagulation factor XII (FXII, Hageman factor) is required for some in
vitro coagulation systems; however, FXII deficiency is not associated with hemorrhage,
leading to the conclusion that it is not necessary for hemostasis. We generated FXII-deficient …
plasma coagulation factors, and the vessel wall. During coagulation in vivo, fibrin formation
is thought to be initiated when plasma factor VIIa forms a complex with the membrane
protein tissue factor. Coagulation factor XII (FXII, Hageman factor) is required for some in
vitro coagulation systems; however, FXII deficiency is not associated with hemorrhage,
leading to the conclusion that it is not necessary for hemostasis. We generated FXII-deficient …
