Activation of the contact system in cerebrospinal fluid of patients with Alzheimer disease
L Bergamaschini, L Parnetti, D Pareyson… - Alzheimer Disease & …, 1998 - journals.lww.com
Several converging lines of evidence suggest that ([beta]-amyloid and inflammation may be
linked in the pathogenesis of Alzheimer disease (AD), but the mechanism of [beta]-amyloid
neurotoxicity is unclear. In this study, by demonstrating that high molecular weight kininogen
may be massively cleaved in the cerebrospinal fluid (CSF) of patients with AD, we provide
evidence of the potential involvement of the contact system in the inflammatory processes
taking place in this disease. In the CSF of patients with neuroimmune inflammatory disease …
linked in the pathogenesis of Alzheimer disease (AD), but the mechanism of [beta]-amyloid
neurotoxicity is unclear. In this study, by demonstrating that high molecular weight kininogen
may be massively cleaved in the cerebrospinal fluid (CSF) of patients with AD, we provide
evidence of the potential involvement of the contact system in the inflammatory processes
taking place in this disease. In the CSF of patients with neuroimmune inflammatory disease …
