[HTML][HTML] Identification of a novel human constitutive androstane receptor (CAR) agonist and its use in the identification of CAR target genes
JM Maglich, DJ Parks, LB Moore, JL Collins… - Journal of Biological …, 2003 - ASBMB
The orphan nuclear constitutive androstane receptor (CAR) is proposed to play a central
role in the response to xenochemical stress. Identification of CAR target genes in humans
has been limited by the lack of a selective CAR agonist. We report the identification of 6-(4-
chlorophenyl) imidazo [2, 1-b][1, 3] thiazole-5-carbaldehydeO-(3, 4-dichlorobenzyl) oxime
(CITCO) as a novel human CAR agonist with the following characteristics:(a) potent activity
in an in vitro fluorescence-based CAR activation assay;(b) selectivity for CAR over other …
role in the response to xenochemical stress. Identification of CAR target genes in humans
has been limited by the lack of a selective CAR agonist. We report the identification of 6-(4-
chlorophenyl) imidazo [2, 1-b][1, 3] thiazole-5-carbaldehydeO-(3, 4-dichlorobenzyl) oxime
(CITCO) as a novel human CAR agonist with the following characteristics:(a) potent activity
in an in vitro fluorescence-based CAR activation assay;(b) selectivity for CAR over other …
