Human biliary epithelial cells secrete and respond to cytokines and hepatocyte growth factors in vitro: interleukin–6, hepatocyte growth factor and epidermal growth …
K Matsumoto, H Fujii, G Michalopoulos, JJ Fung… - Hepatology, 1994 - journals.lww.com
Recombinant growth factors and proinflammatory cytokines were added to primary cultures
of human intrahepatic biliary duct epithelia to test for their ability to stimulate DNA synthesis
and elicit cytokine production. Interleukin–6 and hepatocyte and epidermal growth factors
were found to increase the DNA labeling index of biliary duct epithelium from fourfold to
sixfold 24 hr after their addition to primary biliary duct epithelium cultures maintained in
serum–free medium. The proliferative responses to all three biliary duct epithelium mitogens …
of human intrahepatic biliary duct epithelia to test for their ability to stimulate DNA synthesis
and elicit cytokine production. Interleukin–6 and hepatocyte and epidermal growth factors
were found to increase the DNA labeling index of biliary duct epithelium from fourfold to
sixfold 24 hr after their addition to primary biliary duct epithelium cultures maintained in
serum–free medium. The proliferative responses to all three biliary duct epithelium mitogens …