Increased IL-13-producing T cells in ALS: positive correlations with disease severity and progression rate
N Shi, Y Kawano, T Tateishi, H Kikuchi… - Journal of …, 2007 - Elsevier
We measured the intracellular productions of IFNγ, IL-2, IL-4, IL-13 and TNFα in peripheral
blood CD4+ and CD8+ T cells from 21 amyotrophic lateral sclerosis (ALS) patients, 14
disease controls (DC) with spinocerebellar degeneration and 16 healthy controls (HC). Only
the percentages of CD4+ IL-13+ and CD8+ IL-13+ T cells were significantly higher in ALS
patients than in DC and HC. The CD4+ IL-13+ T cell percentages showed a significant
negative correlation with the revised ALS functional rating scale scores and significant …
blood CD4+ and CD8+ T cells from 21 amyotrophic lateral sclerosis (ALS) patients, 14
disease controls (DC) with spinocerebellar degeneration and 16 healthy controls (HC). Only
the percentages of CD4+ IL-13+ and CD8+ IL-13+ T cells were significantly higher in ALS
patients than in DC and HC. The CD4+ IL-13+ T cell percentages showed a significant
negative correlation with the revised ALS functional rating scale scores and significant …
