[HTML][HTML] Alignment of the transcription start site coincides with increased transcriptional activity from the human asparagine synthetase gene following amino acid …

H Chen, MS Kilberg - The Journal of nutrition, 2006 - Elsevier
Transcription initiation sites of the asparagine synthetase gene were investigated in human
hepatoma cells after amino acid limitation by incubation in amino acid-complete minimal
essential medium or medium lacking histidine. Cells incubated in complete minimal
essential medium had mRNA transcripts with starting positions spanning across the 69
nucleotides immediately upstream of a previously designated transcription start site (+ 1),
whereas the majority of mRNA transcripts started at nucleotide+ 1 in cells incubated in …