[HTML][HTML] Overlapping specificities of the mitochondrial cytochrome c and c1 heme lyases
DG Bernard, ST Gabilly, G Dujardin, S Merchant… - Journal of Biological …, 2003 - ASBMB
Heme attachment to the apoforms of fungal mitochondrial cytochrome c and c 1 requires the
activity of cytochrome c and c 1 heme lyases (CCHL and CC 1 HL), which are enzymes with
distinct substrate specificity. However, the presence of a single heme lyase in higher
eukaryotes is suggestive of broader substrate specificity. Here, we demonstrate that yeast
CCHL is active toward the non-cognate substrate apocytochrome c 1, ie CCHL promotes
low levels of apocytochrome c 1 conversion to its holoform in the absence of CC 1 HL …
activity of cytochrome c and c 1 heme lyases (CCHL and CC 1 HL), which are enzymes with
distinct substrate specificity. However, the presence of a single heme lyase in higher
eukaryotes is suggestive of broader substrate specificity. Here, we demonstrate that yeast
CCHL is active toward the non-cognate substrate apocytochrome c 1, ie CCHL promotes
low levels of apocytochrome c 1 conversion to its holoform in the absence of CC 1 HL …
