[HTML][HTML] Anti-Fas induces hepatic chemokines and promotes inflammation by an NF-κB-independent, caspase-3-dependent pathway
S Faouzi, BE Burckhardt, JC Hanson… - Journal of Biological …, 2001 - ASBMB
Agonistic antibodies against the Fas receptor, when administered to mice in vivo, cause
significant apoptosis in the liver. In this study we show that anti-Fas antibody not only causes
apoptosis of liver cells but also provokes hepatic inflammation. Two hours after injection of
anti-Fas, when mice displayed evidence of caspase-3 activation and apoptosis, we found
significant hepatic induction of the CXC chemokines macrophage inflammatory protein-2
and KC. Coincident with the chemokine induction was infiltration of the hepatic parenchyma …
significant apoptosis in the liver. In this study we show that anti-Fas antibody not only causes
apoptosis of liver cells but also provokes hepatic inflammation. Two hours after injection of
anti-Fas, when mice displayed evidence of caspase-3 activation and apoptosis, we found
significant hepatic induction of the CXC chemokines macrophage inflammatory protein-2
and KC. Coincident with the chemokine induction was infiltration of the hepatic parenchyma …