Interactions of bacterial pathogens with dendritic cells during invasion of mucosal surfaces
F Granucci, P Ricciardi-Castagnoli - Current opinion in microbiology, 2003 - Elsevier
Current opinion in microbiology, 2003•Elsevier
Recent studies of mucosal immunity suggest a key role for dendritic cells in the regulation of
gut immune responses, in both physiological and pathological conditions. Dendritic cells are
widely distributed in the lamina propria of the gut and are involved in direct bacterial uptake
across mucosal surfaces, which questions the role of dendritic cells in innate mucosal
responses. Approximately 400 commensal microbial species are present in the gut lumen.
So how do dendritic cells distinguish pathogens from luminal microflora? Are the cytokines …
gut immune responses, in both physiological and pathological conditions. Dendritic cells are
widely distributed in the lamina propria of the gut and are involved in direct bacterial uptake
across mucosal surfaces, which questions the role of dendritic cells in innate mucosal
responses. Approximately 400 commensal microbial species are present in the gut lumen.
So how do dendritic cells distinguish pathogens from luminal microflora? Are the cytokines …
Recent studies of mucosal immunity suggest a key role for dendritic cells in the regulation of gut immune responses, in both physiological and pathological conditions. Dendritic cells are widely distributed in the lamina propria of the gut and are involved in direct bacterial uptake across mucosal surfaces, which questions the role of dendritic cells in innate mucosal responses. Approximately 400 commensal microbial species are present in the gut lumen. So how do dendritic cells distinguish pathogens from luminal microflora? Are the cytokines and chemokines induced in dendritic cells tailored to the class of microbes being recognized? Several very important questions still need to be addressed.
Elsevier