[HTML][HTML] Troglitazone antagonizes tumor necrosis factor-α-induced reprogramming of adipocyte gene expression by inhibiting the transcriptional regulatory functions of …
H Ruan, HJ Pownall, HF Lodish - Journal of Biological Chemistry, 2003 - ASBMB
Troglitazone (TGZ), a member of the thiazolidinedione class of anti-diabetic compounds and
a peroxisome proliferator activator receptor-γ (PPAR-γ) agonist, restores systemic insulin
sensitivity and improves the full insulin resistance syndrome in vivo. The mechanisms
underlying its in vivo function are not understood. Here we investigated the potential
functional interaction between PPAR-γ and NF-κB in adipocytes. We show that TGZ
selectively blocked tumor necrosis factor-α-induced and NF-κB-dependent repression of …
a peroxisome proliferator activator receptor-γ (PPAR-γ) agonist, restores systemic insulin
sensitivity and improves the full insulin resistance syndrome in vivo. The mechanisms
underlying its in vivo function are not understood. Here we investigated the potential
functional interaction between PPAR-γ and NF-κB in adipocytes. We show that TGZ
selectively blocked tumor necrosis factor-α-induced and NF-κB-dependent repression of …