[HTML][HTML] The lipogenic enzymes DGAT1, FAS, and LPL in adipose tissue: effects of obesity, insulin resistance, and TZD treatment
G Ranganathan, R Unal, I Pokrovskaya… - Journal of lipid …, 2006 - ASBMB
Acyl-coenzyme A: diacylglycerol transferase (DGAT), fatty acid synthetase (FAS), and LPL
are three enzymes important in adipose tissue triglyceride accumulation. To study the
relationship of DGAT1, FAS, and LPL with insulin, we examined adipose mRNA expression
of these genes in subjects with a wide range of insulin sensitivity (SI). DGAT1 and FAS (but
not LPL) expression were strongly correlated with S I. In addition, the expression of DGAT1
and FAS (but not LPL) were higher in normal glucose-tolerant subjects compared with …
are three enzymes important in adipose tissue triglyceride accumulation. To study the
relationship of DGAT1, FAS, and LPL with insulin, we examined adipose mRNA expression
of these genes in subjects with a wide range of insulin sensitivity (SI). DGAT1 and FAS (but
not LPL) expression were strongly correlated with S I. In addition, the expression of DGAT1
and FAS (but not LPL) were higher in normal glucose-tolerant subjects compared with …