Macrophages play key roles in obesity-associated pathophysiology, including inflammation,
atherosclerosis, and cancer, and processes that affect the survival-death balance of
macrophages may have an important impact on obesity-related diseases. Adipocytes and
other cells secrete a protein called extracellular nicotinamide phosphoribosyltransferase
(eNampt; also known as pre-B cell colony enhancing factor or visfatin), and plasma levels of
eNampt increase in obesity. Herein we tested the hypothesis that eNampt could promote cell …