There have recently been increasing experimental and clinical evidences suggesting that
hypothalamic dysregulation may be one of the underlying mechanisms of abnormal glucose
metabolism. First, increased hypothalamic–pituitary–adrenal axis activity induced by
uncontrollable excess stress may cause diabetes mellitus as well as dyslipidemia, visceral
obesity, and osteoporosis with some resemblance to Cushing's disease. Second, several
molecules are known to be expressed both in pancreas and hypothalamus; adenosine …