Although copper is an essential constituent of many physiologic systems, most human
diseases effect minimal changes in copper homeostasis. Therefore, the association of
marked hypercupremia with copper deposition in the ocular media and with a circulating
immunoglobulin G in an apparently healthy woman prompted our interest. Balance and
radioisotopic studies suggest a normal gastrointestinal and renal threshold for copper but a
specific and tight binding between the serum copper and the anomalous protein, the …