Iron accumulation in human chronic renal disease
BJ Nankivell, RA Boadle, DCH Harris - American journal of kidney …, 1992 - Elsevier
BJ Nankivell, RA Boadle, DCH Harris
American journal of kidney diseases, 1992•ElsevierIron, which has been shown to accumulate within proximal tubule lysosomes in proteinuric
models of renal disease, may play a role in the progression of chronic renal disease by the
generation of reactive oxygen species. Therefore, renal biopsies from humans with
proteinuria and/or chronic renal failure were examined at an ultrastructural level for iron by
energy dispersive analysis and compared with normal biopsies. Iron accumulated in
proximal tubular lysosomes in renal disease (P< 0.05 v normals), accompanied in some …
models of renal disease, may play a role in the progression of chronic renal disease by the
generation of reactive oxygen species. Therefore, renal biopsies from humans with
proteinuria and/or chronic renal failure were examined at an ultrastructural level for iron by
energy dispersive analysis and compared with normal biopsies. Iron accumulated in
proximal tubular lysosomes in renal disease (P< 0.05 v normals), accompanied in some …
Iron, which has been shown to accumulate within proximal tubule lysosomes in proteinuric models of renal disease, may play a role in the progression of chronic renal disease by the generation of reactive oxygen species. Therefore, renal biopsies from humans with proteinuria and/or chronic renal failure were examined at an ultrastructural level for iron by energy dispersive analysis and compared with normal biopsies. Iron accumulated in proximal tubular lysosomes in renal disease (P < 0.05 v normals), accompanied in some cases by phosphorus and silicon. Both the number of iron-containing lysosomes per tubular cross-section (1.86 ± 0.41 v 0.66 ± 0.22, P < 0.05) and the mean concentration of lysosomal iron (254.5 ± 73.4 mg/dL v 81.2 ± 23.8, P < 0.001) was greater in patients with nephrotic syndrome (n = 12) than in those without (n = 8). Iron accumulation (number of iron-containing lysosomes/tubule) correlated with protein excretion (r = 0.68, P = 0.003, n = 20), but not with glomerular filtration rate. Damaged tubules contained greater amounts of iron than tubules with less damage (288.5 ± 68.5 mg/dL v 80.4 ± 13.9, P < 0.01). Further studies are needed to define the possible role of iron in causing tubular damage and progression of renal disease.
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