Endothelin-1-induced prostaglandin E2-EP2, EP4 signaling regulates vascular endothelial growth factor production and ovarian carcinoma cell invasion
F Spinella, L Rosanò, V Di Castro, PG Natali… - Journal of Biological …, 2004 - ASBMB
Cyclooxygenase (COX)-1-and COX-2-derived prostaglandins are implicated in the
development and progression of several malignancies. We have recently demonstrated that
treatment of ovarian carcinoma cells with endothelin-1 (ET-1) induces expression of both
COX-1 and COX-2, which contributes to vascular endothelial growth factor (VEGF)
production. In this study, we show that in HEY and OVCA 433 ovarian carcinoma cells, ET-1,
through the binding with ET A receptor (ET AR), induces prostaglandin E2 (PGE 2) …
development and progression of several malignancies. We have recently demonstrated that
treatment of ovarian carcinoma cells with endothelin-1 (ET-1) induces expression of both
COX-1 and COX-2, which contributes to vascular endothelial growth factor (VEGF)
production. In this study, we show that in HEY and OVCA 433 ovarian carcinoma cells, ET-1,
through the binding with ET A receptor (ET AR), induces prostaglandin E2 (PGE 2) …
