Nonrandom loss of maternal chromosome 11 alleles in Wilms tumors.
WT Schroeder, LY Chao, DD Dao… - American journal of …, 1987 - ncbi.nlm.nih.gov
WT Schroeder, LY Chao, DD Dao, LC Strong, S Pathak, V Riccardi, WH Lewis, GF Saunders
American journal of human genetics, 1987•ncbi.nlm.nih.govA series of gene probes for chromosome 11 has been used to study the genetic events
associated with the development of Wilms tumor. Examination of DNA samples from five
patients with Wilms tumor in whom the tumors showed loss of chromosome 11 alleles and
their parents indicate that alleles lost in the tumors are of maternal origin. These data
suggest that the parental derivation of chromosome 11 alleles lost in these Wilms tumors is
not random.
associated with the development of Wilms tumor. Examination of DNA samples from five
patients with Wilms tumor in whom the tumors showed loss of chromosome 11 alleles and
their parents indicate that alleles lost in the tumors are of maternal origin. These data
suggest that the parental derivation of chromosome 11 alleles lost in these Wilms tumors is
not random.
Abstract
A series of gene probes for chromosome 11 has been used to study the genetic events associated with the development of Wilms tumor. Examination of DNA samples from five patients with Wilms tumor in whom the tumors showed loss of chromosome 11 alleles and their parents indicate that alleles lost in the tumors are of maternal origin. These data suggest that the parental derivation of chromosome 11 alleles lost in these Wilms tumors is not random.
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