Angiogenesis, adipokines and breast cancer

L Vona-Davis, DP Rose - Cytokine & growth factor reviews, 2009 - Elsevier
The prevalence of overweight and obesity is rapidly increasing world wide. Numerous
epidemiological studies have shown that obesity is a risk factor for postmenopausal breast
cancer and relapse. However, the biological factors that drive the growth and progression of
these tumors and how obesity contributes to the tumor microenvironment are poorly
understood. Tumor development and metastasis are dependent on the process of
angiogenesis or the formation of new blood vessels. More importantly, a ready supply of …