Suppressive antibacterial therapy with 0.75% metronidazole vaginal gel to prevent recurrent bacterial vaginosis
JD Sobel, D Ferris, J Schwebke, P Nyirjesy… - American journal of …, 2006 - Elsevier
OBJECTIVE: Efficacy study of suppressive vaginal metronidazole in reducing recurrent
symptomatic episodes of bacterial vaginosis. STUDY DESIGN: Multicenter prospective study
with initial 10-day open-label metronidazole gel in which asymptomatic responders
randomly assigned to receive twice weekly metronidazole vaginal gel or placebo for 16
weeks and off therapy for 12 weeks. RESULTS: Of 157 eligible women with recurrent
bacterial vaginosis, 112 of 127 returning evaluable women (88.2%) responded clinically and …
symptomatic episodes of bacterial vaginosis. STUDY DESIGN: Multicenter prospective study
with initial 10-day open-label metronidazole gel in which asymptomatic responders
randomly assigned to receive twice weekly metronidazole vaginal gel or placebo for 16
weeks and off therapy for 12 weeks. RESULTS: Of 157 eligible women with recurrent
bacterial vaginosis, 112 of 127 returning evaluable women (88.2%) responded clinically and …