[PDF][PDF] The mucosal immune system and HIV-1 infection
Recent progress in HIV-1 and SIV pathogenesis has revealed that mucosal tissues, primarily
the gastrointestinal tract, are major sites for early viral replication and CD4+ T-cell
destruction, and may be the major viral reservoir, even in patients receiving HAART. This is
likely attributable to the fact that the majority of mucosal CD4+ T-cells co-expressing
chemokine receptors required for HIV-1 entry, reside in mucosal tissues. Furthermore, the
intestinal mucosal immune system is continuously bombarded by dietary antigens, resulting …
the gastrointestinal tract, are major sites for early viral replication and CD4+ T-cell
destruction, and may be the major viral reservoir, even in patients receiving HAART. This is
likely attributable to the fact that the majority of mucosal CD4+ T-cells co-expressing
chemokine receptors required for HIV-1 entry, reside in mucosal tissues. Furthermore, the
intestinal mucosal immune system is continuously bombarded by dietary antigens, resulting …