Effect of human papillomavirus 16/18 L1 viruslike particle vaccine among young women with preexisting infection: a randomized trial
A Hildesheim, R Herrero, S Wacholder, AC Rodriguez… - Jama, 2007 - jamanetwork.com
ContextViruslike particle human papillomavirus (HPV) vaccines were designed to prevent
HPV infection and development of cervical precancers and cancer. Women with oncogenic
HPV infections might consider vaccination as therapy. ObjectiveTo determine whether
vaccination against HPV types 16 and 18 increases the rate of viral clearance in women
already infected with HPV. Design and SettingPhase 3, masked, community-based
randomized trial conducted in 2 provinces of Costa Rica. ParticipantsA total of 2189 women …
HPV infection and development of cervical precancers and cancer. Women with oncogenic
HPV infections might consider vaccination as therapy. ObjectiveTo determine whether
vaccination against HPV types 16 and 18 increases the rate of viral clearance in women
already infected with HPV. Design and SettingPhase 3, masked, community-based
randomized trial conducted in 2 provinces of Costa Rica. ParticipantsA total of 2189 women …