TIR-containing adapter molecule (TICAM)-2, a bridging adapter recruiting to Toll-like receptor 4 TICAM-1 that induces interferon-β
H Oshiumi, M Sasai, K Shida, T Fujita… - Journal of Biological …, 2003 - ASBMB
Lipopolysaccharide (LPS) is an agonist for Toll-like receptor (TLR) 4 and expresses many
genes including NF-κB-and interferon regulatory factor (IRF)-3/IFN-inducible genes in
macrophages and dendritic cells (DCs). TICAM-1/TRIF was identified as an adapter that
facilitates activation of IRF-3 followed by expression of interferon (IFN)-β genes in TLR3
signaling, but TICAM-1 does not directly bind TLR4. Although MyD88 and Mal/TIRAP
adapters functions downstream of TLR4, DC maturation and IFN-β induction are …
genes including NF-κB-and interferon regulatory factor (IRF)-3/IFN-inducible genes in
macrophages and dendritic cells (DCs). TICAM-1/TRIF was identified as an adapter that
facilitates activation of IRF-3 followed by expression of interferon (IFN)-β genes in TLR3
signaling, but TICAM-1 does not directly bind TLR4. Although MyD88 and Mal/TIRAP
adapters functions downstream of TLR4, DC maturation and IFN-β induction are …
