[HTML][HTML] Actin-depolymerizing factor cofilin-1 is necessary in maintaining mature podocyte architecture
Actin dynamics determines podocyte morphology during development and in response to
podocyte injury and might be necessary for maintaining normal podocyte morphology.
Because podocyte intercellular junction receptor Nephrin plays a role in regulating actin
dynamics, and given the described role of cofilin in actin filament polymerization and
severing, we hypothesized that cofilin-1 activity is regulated by Nephrin and is necessary in
normal podocyte actin dynamics. Nephrin activation induced cofilin dephosphorylation via …
podocyte injury and might be necessary for maintaining normal podocyte morphology.
Because podocyte intercellular junction receptor Nephrin plays a role in regulating actin
dynamics, and given the described role of cofilin in actin filament polymerization and
severing, we hypothesized that cofilin-1 activity is regulated by Nephrin and is necessary in
normal podocyte actin dynamics. Nephrin activation induced cofilin dephosphorylation via …