Prevention of high-fat diet-induced muscular lipid accumulation in rats by α lipoic acid is not mediated by AMPK activation [S]
S Timmers, J De Vogel-Van Den Bosch… - Journal of lipid …, 2010 - ASBMB
Skeletal muscle triglyceride accumulation is associated with insulin resistance in obesity.
Recently, it has been suggested that α lipoic acid (ALA) improves insulin sensitivity by
lowering triglyceride accumulation in nonadipose tissues via activation of skeletal muscle
AMP-activated protein kinase (AMPK). We examined whether chronic ALA supplementation
prevents muscular lipid accumulation that is associated with high-fat diets via activation of
AMPK. In addition, we tested if ALA supplementation was able to improve insulin sensitivity …
Recently, it has been suggested that α lipoic acid (ALA) improves insulin sensitivity by
lowering triglyceride accumulation in nonadipose tissues via activation of skeletal muscle
AMP-activated protein kinase (AMPK). We examined whether chronic ALA supplementation
prevents muscular lipid accumulation that is associated with high-fat diets via activation of
AMPK. In addition, we tested if ALA supplementation was able to improve insulin sensitivity …
