[HTML][HTML] In vitro suppression of the lipogenic pathway by the nonnucleoside reverse transcriptase inhibitor efavirenz in 3T3 and human preadipocytes or adipocytes
K El Hadri, M Glorian, C Monsempes… - Journal of Biological …, 2004 - ASBMB
A serious metabolic syndrome combining insulin-resistance, dyslipidemia, central adiposity,
and peripheral lipoatrophy has arisen in HIV-infected patients receiving highly active
antiretroviral therapy. The aim of this work was to examine the effects of the nonnucleoside
reverse transcriptase inhibitor (NNRTI) efavirenz on adipocyte differentiation and
metabolism. When induced to differentiate in the presence of efavirenz (5–50 μm), 3T3-
F442A preadipocytes failed to accumulate cytoplasmic triacylglycerol droplets. This …
and peripheral lipoatrophy has arisen in HIV-infected patients receiving highly active
antiretroviral therapy. The aim of this work was to examine the effects of the nonnucleoside
reverse transcriptase inhibitor (NNRTI) efavirenz on adipocyte differentiation and
metabolism. When induced to differentiate in the presence of efavirenz (5–50 μm), 3T3-
F442A preadipocytes failed to accumulate cytoplasmic triacylglycerol droplets. This …
